Fold recognition without folds

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چکیده

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Improving fold recognition without folds.

The most reliable way to align two proteins of unknown structure is through sequence-profile and profile-profile alignment methods. If the structure for one of the two is known, fold recognition methods outperform purely sequence-based alignments. Here, we introduced a novel method that aligns generalised sequence and predicted structure profiles. Using predicted 1D structure (secondary structu...

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Predicting Protein Folds with Fold-Specific PSSM Libraries

Accurately assigning folds for divergent protein sequences is a major obstacle to structural studies. Herein, we outline an effective method for fold recognition using sets of PSSMs, each of which is constructed for different protein folds. Our analyses demonstrate that FSL (Fold-specific Position Specific Scoring Matrix Libraries) can predict/relate structures given only their amino acid seque...

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ژورنال

عنوان ژورنال: Protein Science

سال: 2002

ISSN: 0961-8368,1469-896X

DOI: 10.1110/ps.3590102